Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the gallbladder

Abstract Background Signet ring cell carcinoma (SRC) is a rare histological subtype of gallbladder adenocarcinoma. The current study evaluates the clinicopathologic features and prognosis SRC. Methods Patients with adenocarcinoma were identified in Surveillance, Epidemiology, End Results database from 1973 to 2016. Overall survival (OS) cancer-specific (CSS) patients who had SRC compared those non-SRC using Cox regression propensity score methods. Of 22,781 adenocarcinomas retrieved, 377 (1.7%) other 22,404 non-SRC. was more significantly associated older age, female gender, poor differentiation, advanced tumor stage, lymph node metastasis, distant AJCC stage. 5-year OS CSS group 7.2 6.5%, respectively, both which worse than 13.2 13.3% seen ( P = 0.002 0.012, respectively). This disadvantage persisted multivariable analyses [hazard ratio (HR) 1.256, 0.021 HR 1.211, 0.036] after matching (OS: 1.341, 0.012 CSS: 1.625, 0.005). Surgery combination chemotherapy improved surgery alone (HR 0.726, 0.036) or 0.433, < 0.001). Conclusion have distinct clinicopathological prognosis. can improve survival.